Clinical Value of Seven Autoantibodies Against Tumor-Associated Antigens and Tumor Markers in Lung Cancer Patients: A Retrospective Analysis from a Single Institution

Clinical Value of Seven Autoantibodies Against Tumor-Associated Antigens and Tumor Markers in Lung Cancer Patients: A Retrospective Analysis from a Single Institution

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Background: Lung cancer screening is not limited to low dose computed tomography (LDCT).Recently, molecular biomarkers have been shown to have the potential to improve the current battery-powered generators state of early lung cancer detection.The current study determined the efficiency of seven autoantibodies against tumor-associated antigens (7-AABs) and tumor markers in patients with lung cancer.Materials and Methods: An enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of 7-AABs and tumor markers in 354 patients with lung cancer and 108 patients with benign pulmonary disease under care at Ethics Committee of Tianjin Medical University General Hospital.Results: The sensitivity, specificity, positive predictive value (PPV), and area under the receiver operating characteristic (ROC) curve of 7-AABs were 30.

0%, 84.3%, 86.3%, and 0.61, respectively.When combining the 7-AABs and tumor markers, the sensitivity was 68.

6%, the specificity was 52.8%, and the area under the ROC curve was 0.72.The 7-AABs positive expression rate in lung cancer patients was significantly higher than patients North Dakota with benign pulmonary diseases (30.1% vs 15.

7%); however, the 7-AABs positive expression rate was affected by clinical features and pathologic stages.When combining 7-AABs and tumor markers, the combined 7-AABs and tumor marker positive expression rate increased to 68.6%.Conclusion: Based on this study and previous literature, the supplemental diagnostic value of 7-AABs has been confirmed; however, due to the low sensitivity, the value of 7-AABs alone in lung cancer screening is limited.The combination of 7-AABs and tumor markers has improved sensitivity and positivity, but decreased specificity, which makes their performance in cancer screening and early detection worthy of further research.